In the MagBio project, we will develop a completely new type of biotechnological production system: living biofilms that grow on magnetic nanoparticles and can be precisely shaped using magnetic fields. “These intelligent biocatalysts” are not only more robust than conventional systems but can also flexibly adapt their architecture – for maximum productivity and resource efficiency.

This interdisciplinary research project develops innovative biofilm systems for the production of 2,3-butanediol – an important platform chemical for biopolymers and fuels. The core idea is the use of magnetic nanoparticles on which biofilms of the bacterium Shewanella oneidensis grow. Magnetic fields allow for precise control of the biofilm’s structure, density, and position. These “magnetic biofilms” enable improved mass transport dynamics and increase productivity.

The project will create a scalable platform that utilizes biofilms as robust biocatalysts in continuous processes. A central element is our developed robotics platform, which automatically monitors biofilms, magnetically rearranges them, and analyzes their activity using various imaging techniques – a digital twin of living production systems. Thus, MagBio contributes to the establishment of sustainable biotechnological production methods.