Research Project
StrepBio2Films will explore and optimize productive biofilm formation of Streptomyces for antibiotic production in continuous tubular bioreactors, leveraging genetic tools and physiological insights – especially c-di-GMP signaling and biofilm matrix synthesis.
Streptomyces species are prolific producers of antibiotics, yet their industrial cultivation in stirred-tank bioreactors is hampered by issues such as shear stress, oxygen limitation, and morphological complexity of these filamentous bacteria. Our StrepBio2Films project, pioneers a novel approach by cultivating Streptomyces as productive biofilms in continuous tubular bioreactors that mimic their life-style in natural growth environment soil. Leveraging cutting-edge bioreactor engineering and fluorescence microscopy, the study investigates how environmental gradients and the bacterial second messenger c-di-GMP regulate biofilm formation, architecture, and antibiotic production. This interdisciplinary effort promises to transform
StrepBio2Films project explores Streptomycesbiofilm growth within continuous tubular reactors, where specific parameters influence cell physiology and secondary metabolism. Central to this regulation is the bacterial second messenger c-di-GMP, which controls the synthesis of the extracellular biofilm matrix and thus biofilm architecture and productivity. This interdisciplinary research integrates molecular microbiology, bioprocess engineering, and molecular signaling to optimize Streptomyces biofilms for antibiotic production.
Insight into the StrepBio2Films research project.
